The centrosome has been proposed to lead the way during neuronal migration and to determine the site of axonogenesis, although whether this applies to all types of neuron is unclear. To investigate centrosome dynamics in vivo, Distel et al. develop a new method to simultaneously visualize the centrosome and other subcellular structures in live zebrafish embryos. The researchers conclude that the centrosome does not lead migration or determine axon position in neurons derived from the hindbrain rhombic lip.
Download our Journal Club pack to aid your discussion of Distel et al.’s study, and its implications for both centrosome positioning and the future of in vivo cell biology. The pack includes a complete pdf of the paper, a PowerPoint file of Distel et al.’s figures, supplementary videos, and the latest biosights video podcast, which features an interview with the study’s senior author Reinhard Köster (Helmholtz Zentrum, Munich, Germany).
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