The centrosome remains closely associated with the nucleus throughout the cell cycle. Bolhy et al. reveal that the nucleoporin Nup133 anchors a network of proteins, including the motor protein dynein, that tethers centrosomes to nuclear pores in early prophase to assist the early stages of mitotic spindle assembly.
Download our Journal Club pack to aid your discussion of Bolhy et al.’s study, and its implications for centrosome positioning. The pack includes a complete pdf of the paper, a PowerPoint file of Bolhy et al.’s figures, supplementary videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Valérie Doye (Institut Jacques Monod, Paris, France).