The mammalian Golgi apparatus exists as a continuous ribbon that clusters around the centrosome, but the significance of this organization is unclear. Hurtado et al. identify truncation mutants of the protein AKAP450 that differentially affect Golgi integrity and positioning, and use these mutants to investigate how the Golgi’s organization contributes to its function.
Download our Journal Club pack to aid your discussion of Hurtado et al.’s study, and its implications for the Golgi’s function in polarization, migration and ciliogenesis. The pack includes a complete pdf of the paper, a PowerPoint file of Hurtado et al.’s figures, supplementary videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Rosa Rios (CABIMER, Seville, Spain).