When a T cell encounters a target antigen-presenting cell, the lymphocyte’s centrosome relocalizes to a specialized contact between the two cells called the immunological synapse. Zyss et al. reveal that casein kinase Iδ helps to reposition the centrosome in activated T cells, perhaps by working with the microtubule plus-end binding protein EB1 to regulate microtubule growth.
Download our Journal Club pack to aid your discussion of Zyss et al.’s study, and its implications for centrosome polarization during T cell activation. The pack includes a complete pdf of the paper, a PowerPoint file of Zyss et al.’s figures, supplementary videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Fanni Gergely (University of Cambridge and Cancer Research UK).