Desmosomes are intercellular adhesions whose adhesive core is formed by two distinct classes of cadherin molecules – desmogleins and desmocollins. Nekrasova et al. reveal that these two cadherins are independently transported to the cell surface by two different kinesin motors.
Download our Journal Club pack to aid your discussion of Nekrasova et al.’s study, and its implications for desmosome assembly and intercellular adhesion. The pack includes a complete pdf of the paper, a PowerPoint file of Nekrasova et al.’s figures, supplementary videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Kathleen Green (Northwestern University Feinberg School of Medicine, Chicago, IL).