T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they invade through tissues. Gilden et al. reveal that septins function by assembling on membrane blebs to retract them back into shape.
Download our Journal Club pack to aid your discussion of Gilden et al.’s study, and its implications for membrane blebbing and T cell motility. The pack includes a complete pdf of the paper, a PowerPoint file of Gilden et al.’s figures, supplementary videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Max Krummel (University of California, San Francisco).