Autophagy is a cellular degradation pathway essential for neuronal survival, but little is known about the dynamics of autophagic organelles in neurons. Maday et al. reveal that autophagosomes form and engulf cargo at the distal tips of neurites and then mature into degradative autolysosomes as they move toward the cell body.
Download our Journal Club pack to aid your discussion of Maday et al.’s study, and its implications for the spatial and temporal regulation of autophagy. The pack includes a complete pdf of the paper, a PowerPoint file of Maday et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with two of the study’s authors, Sandra Maday and Erika Holzbaur (University of Pennsylvania, Philadelphia).