The adhesions between endothelial cells transiently remodel in response to angiogenic growth factors and inflammatory cytokines. Huveneers et al. reveal that remodeling takes place at a subset of adhesions called focal adherens junctions, which recruit the mechanosensory protein Vinculin to resist tension from the actomyosin cytoskeleton and avoid excessive disruption during the remodeling process.
Download our Journal Club pack to aid your discussion of Huveneers et al.’s study and its implications for endothelial junction remodeling and mechanosensing. The pack includes a complete pdf of the paper, a PowerPoint file of Huveneers et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Johan de Rooij (Hubrecht Institute, Utrecht, The Netherlands).