Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating fibroblasts, but their exact function in persistent motility remains unclear. Welf et al. reveal that PI3K signaling helps reorient migrating fibroblasts by stabilizing branched protrusions at the leading edge, allowing the cell to pivot and move in a different direction.
Download our Journal Club pack to aid your discussion of Welf et al.’s study and its implications for persistent migration and chemotaxis. The pack includes a complete pdf of the paper, a PowerPoint file of Welf et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Jason Haugh (North Carolina State University, Raleigh, NC).