Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how cells move through three-dimensional environments is less well understood. Petrie et al. reveal that, depending on the strength of intracellular RhoA signaling and on the elastic properties of the extracellular matrix, fibroblasts can migrate through 3D environments using either lamellipodia or blunt, cylindrical protrusions called lobopodia.
Download our Journal Club pack to aid your discussion of Petrie et al.’s study and its implications for fibroblast migration and cell polarity. The pack includes a complete pdf of the paper, a PowerPoint file of Petrie et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s first author, Ryan Petrie (NIH, Bethesda, MD).