Activated T cell receptors stimulate actin polymerization at the periphery of the immunological synapses that form between lymphocytes and antigen-presenting cells. Babich et al. reveal that the retrograde flow of actin, largely driven by continuous polymerization, is required to sustain downstream signaling events and T cell activation.
Download our Journal Club pack to aid your discussion of Babich et al.’s study and its implications for T cell signaling. The pack includes a complete pdf of the paper, a PowerPoint file of Babich et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Janis Burkhardt (University of Pennsylvania, Philadelphia).