The mechanical properties of the extracellular matrix are known to regulate the migration of single cells, but whether substrate stiffness also affects collective cell migration is unclear. Ng et al. reveal that epithelial sheets move faster on stiffer matrices due to increased myosin contractility and mechanical coupling through cell-cell adhesions.
Download our Journal Club pack to aid your discussion of Ng et al.’s study and its implications for cell coordination and collective migration. The pack includes a complete pdf of the paper, a PowerPoint file of Ng et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with three of the study’s authors, Rosa Ng, Gaudenz Danuser, and Joan Brugge (Harvard Medical School, Boston, MA).