Under certain conditions, cells form protrusions that oscillate rapidly around the cell periphery. Kapustina et al. reveal that these oscillatory protrusions, which may be related to processes involved in amoeboid cell migration, are driven by the cyclic folding and unfolding of the plasma membrane and its underlying actin cortex.
Download our Journal Club pack to aid your discussion of Kapustina et al.’s study and its implications for cell shape changes and amoeboid-type migration. The pack includes a complete pdf of the paper, a PowerPoint file of Kapustina et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s lead author, Maryna Kapustina (University of North Carolina, Chapel Hill).