When leukocytes enter or exit the blood stream, they leave small wounds both in and between the vascular endothelial cells, which must be quickly repaired so that the endothelium can maintain its barrier function. Martinelli et al. reveal that wounding causes a loss of tension in endothelial cells, inducing the formation of ventral lamellipodia that close the holes left by transmigrating leukocytes.
Download our Journal Club pack to aid your discussion of Martinelli et al.’s study and its implications for transendothelial migration and mechanobiology. The pack includes a complete pdf of the paper, a PowerPoint file of Martinelli et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with two of the study’s authors, Roberta Martinelli and Christopher Carman (Harvard Medical School, Boston, MA).