Cell invasion through basement membranes is crucial for both normal development and cancer metastasis but relatively little is known about the process because it is difficult to observe in vivo. By imaging the invasion of anchor cells during C. elegans development, Hagedorn et al. reveal that, after invadopodia-like structures form an initial breach in the basement membrane, localized netrin signaling helps generate a stable invasive protrusion that widens the gap and directs the cell across the extracellular barrier.
Download our Journal Club pack to aid your discussion of Hagedorn et al.’s study and its implications for cell invasion. The pack includes a complete pdf of the paper, a PowerPoint file of Hagedorn et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s senior author, David Sherwood (Duke University, Durham, NC).