Epithelial cells around the edge of a wound assemble an actomyosin cable that constricts to draw the wound closed, but the events that precede cable formation are largely unknown. Antunes et al. reveal that wounding induces a wave of actomyosin assembly and cell constriction that flows toward the wound edge to promote cable assembly and tissue repair.
Download our Journal Club pack to aid your discussion of Antunes et al.’s study and its implications for epithelial wound repair. The pack includes a complete pdf of the paper, a PowerPoint file of Antunes et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Antonio Jacinto (NOVA, Lisbon, Portugal).