The discoid shape of resting platelets is maintained by a peripheral ring of bundled microtubules called the marginal band. Diagouraga et al. reveal that, upon platelet activation, the motor protein dynein slides microtubules apart, inducing marginal band coiling and the conversion of platelets to a spherical shape.
Download our Journal Club pack to aid your discussion of Diagouraga et al.’s study and its implications for platelet activation and cell shape changes. The pack includes a complete pdf of the paper, a PowerPoint file of Diagouraga et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Karin Sadoul (Institut Albert Bonniot, Grenoble, France).