During development, the planar polarized distribution of Rho kinase and Myosin II helps Drosophila germ-band cells intercalate so that the embryo extends along its anterior-posterior axis. Simões et al. reveal how Rho GTPase and the actin-binding protein Shroom combine to regulate the localization of Rho kinase and actomyosin contractility during axis elongation.
Download our Journal Club pack to aid your discussion of Simões et al.’s study and its implications for planar polarity and convergent extension. The pack includes a complete pdf of the paper, a PowerPoint file of Simões et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s first author, Sérgio de Matos Simões (formerly at Memorial Sloan Kettering Cancer Center, New York and currently at the University of Toronto).