The lamella is a broad, flat region that forms at the front of migrating cells and adheres to the underlying substrate. Burnette et al. reveal that cells flatten out the lamella by mechanically coupling a contractile actomyosin network at the dorsal surface to ventral cell adhesions.
Download our Journal Club pack to aid your discussion of Burnette et al.’s study and its implications for cell shape changes and migration. The pack includes a complete pdf of the paper, a PowerPoint file of Burnette et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with two of the study’s authors, Dylan Burnette (Vanderbilt University School of Medicine, Nashville, TN) and Jennifer Lippincott-Schwartz (NICHD, Bethesda, MD).