The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what happens to these structures when cells detach from a monolayer during development or disease is unclear. Klingner et al. reveal that non-confluent epithelial cells form longer, more dynamic microvilli on their apical surface that connect to a cortical actomyosin network.
Download our Journal Club pack to aid your discussion of Klingner et al.’s study and its implications for apical organization and epithelial morphogenesis. The pack includes a complete pdf of the paper, a PowerPoint file of Klingner et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the paper’s senior author, Roland Wedlich-Söldner (University of Münster, Germany).