Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly understood. Jones et al. reveal that dynein's light intermediate chains are required to maintain centrosome integrity during mitosis, preventing the premature separation of mother-daughter centrioles and the formation of multipolar spindles.
Download our Journal Club pack to aid your discussion of Jones et al.'s study and its implications for dynein function and force balances within the mitotic spindle. The pack includes a complete pdf of the paper, a PowerPoint file of Jones et al.'s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the paper’s senior authors, Viki Allan and Sarah Woolner (University of Manchester, UK).