Migrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions at the cell's leading edge. Johnson et al. reveal that filopodial protrusions initiate and orient these lamellipodia, helping fibroblasts navigate gradients of immobilized guidance cues.
Download our Journal Club pack to aid your discussion of Johnson et al.'s study and its implications for directed cell migration. The pack includes a complete pdf of the paper, a PowerPoint file of Johnson et al.'s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the paper's senior author, Jason Haugh (North Carolina State University, Raleigh, NC).