Brachet's cleft separates the ectoderm and mesoderm of early Xenopus and zebrafish embryos. Luu et al. reveal that, in conjunction with the transcription factor Snail1, the protocadherin PAPC promotes tissue separation by downregulating planar cell polarity proteins at the ectoderm-mesoderm boundary.
Download our Journal Club pack to aid your discussion of Luu et al.'s study and its implications for tissue separation and self/non-self recognition. The pack includes a complete pdf of the paper, a PowerPoint file of Luu et al.'s figures, supplemental videos, and the latest biosights video podcast, which features an interview with one of the paper's senior authors, Rudolf Winklbauer (University of Toronto, Toronto, Canada).