The BLOC-2 complex contains three subunits encoded by genes mutated in Hermansky-Pudlak syndrome, a disease caused by defects in the trafficking pathways that form melanosomes and other lysosome-related organelles. Dennis et al. reveal that the BLOC-2 complex promotes the delivery of melanosomal cargo by targeting recycling endosomal tubules to maturing melanosomes.
Download our Journal Club pack to aid your discussion of Dennis et al.'s study and its implications for melanosome biogenesis. The pack includes a complete pdf of the paper, a PowerPoint file of Dennis et al.'s figures, supplemental videos, and the latest biosights video podcast, which features an interview with one of the paper's senior authors, Michael Marks (University of Pennsylvania, Philadelphia, PA).