Centrosomes undergo dramatic changes in size and structure during the rapid cell cycles of early Drosophila embryos. Lerit et al. reveal that a scaffold formed by the proteins centrosomin and PLP is required to maintain interphase centrosome activity, which is essential for nuclear spacing and proper chromosome segregation.
Download our Journal Club pack to aid your discussion of Lerit et al.'s study and its implications for the organization and function of interphase centrosomes. The pack includes a complete pdf of the paper, a PowerPoint file of Lerit et al.'s figures, supplemental videos, and the latest biosights video podcast, which features an interview with two of the paper's authors, Dorothy Lerit and Nasser Rusan (National Heart, Lung, and Blood Institute, Bethesda, MD).