After entering a cell, many viruses move toward the nucleus by binding to the microtubule-based motor protein dynein. Jovasevic et al. reveal, however, that herpes simplex virus must first associate with the plus ends of microtubules in a process that requires the dynein accessory factor dynactin and the plus end tracking proteins EB1 and CLIP-170.
Download our Journal Club pack to aid your discussion of Jovasevic et al.'s study and its implications for viral transport and cargo capture by microtubule plus ends. The pack includes a complete pdf of the paper, a PowerPoint file of Jovasevic et al.'s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the paper’s corresponding author, Derek Walsh (Northwestern University, Chicago, IL).