During meiosis, oocytes must attach homologous chromosomes to opposite spindle poles, but the cells take several hours to assemble a bipolar spindle. Głuszek et al. reveal that, in Drosophila oocytes, the microtubule catastrophe–promoting protein Sentin delays the formation of stable kinetochore–microtubule attachments until spindle assembly is complete, thereby preventing homologous chromosomes from incorrectly attaching to the same spindle pole.
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