Exosomes are small, extracellular vesicles that transfer lipid, protein, and RNA cargoes between cells, but relatively little is known about how they are taken up and processed by their target cells. Heusermann et al. reveal that exosomes "surf" along recipient cell filopodia before being efficiently endocytosed and targeted to the endoplasmic reticulum.
Download our Journal Club pack to aid your discussion of Heusermann et al.'s study and its implications for exosome uptake and the delivery of therapeutic RNAs. The pack includes a complete PDF of the paper, a PowerPoint file of Heusermann et al.'s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the paper's senior author, Nicole Meisner-Kober (Novartis Institutes for Biomedical Research, Basel, Switzerland).