The obligate intracellular bacterium Chlamydia trachomatis must keep its host cell alive, even though it produces reactive oxygen species that expose the host cell to oxidative stress. Chowdhury et al. reveal that Chlamydia mitigates this oxidative stress by down-regulating the mitochondrial fission protein DRP1 via a microRNA- and p53-dependent pathway, thereby maintaining the mitochondrial network and ATP production to promote host cell survival and bacterial growth.Download our Journal Club pack pack to aid your discussion of Chowdhury et al.'s study and its implications for host-pathogen interactions. The pack includes a complete pdf of the paper, supplemental videos, and the latest biosights video podcast, which features an interview with two of the paper's authors, Suvagata Roy Chowdhury and Thomas Rudel (University of Würzburg, Würzburg, Germany).