During the first meiotic division of mammalian oocytes, the meiotic spindle and chromosomes move from the interior to the periphery of the cell. Yi et al. reveal that chromosome migration occurs in two sequential phases driven by the actin nucleators Fmn2 and the Arp2/3 complex.
Download our Journal Club pack to aid your discussion of Yi et al.’s study and its implications for chromosome migration and symmetry breaking. The pack includes a complete pdf of the paper, a PowerPoint file of Yi et al.’s figures, supplemental videos, and the latest biosights video podcast, which features an interview with the study’s senior author, Rong Li (Stowers Institute for Medical Research, Kansas City, MO).
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