Dynamics of in vivo ASC speck formation

September 04, 2017

Dynamics of in vivo ASC speck formation

Invading pathogens or other toxic agents can trigger the assembly of the inflammasome adaptor ASC into large, intracellular specks that activate caspase-1 to initiate a proinflammatory cell death called pyroptosis. Kuri et al. follow the dynamics of ASC speck formation in live zebrafish, revealing their lethal effects on epidermal keratinocytes and their subsequent engulfment and degradation by macrophages.

Download our Journal Club pack to aid your discussion of Kuri et al.'s study and its implications for inflammasome assembly and innate immunity in vivo. The pack includes a complete PDF of the paper, supplemental videos, and the latest biosights video podcast, which features an interview with two of the paper's authors, Paola Kuri and Maria Leptin (EMBL).

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The Journal of Cell Biology’s Journal Club packs are designed to enhance discussion of the latest research published in the JCB. Each month, we select an outstanding recent paper from the journal and provide links to download the manuscript pdf, a PowerPoint file of the paper’s figures, supplementary videos, and an accompanying biosights video, featuring interviews with the paper’s authors.

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September 04, 2017