Enucleated cells in migration and mechanotransduction

In addition to its roles in DNA replication and gene expression, the nucleus has an important physical impact on cellular behavior. Graham et al. reveal that, although the nucleus is dispensable for cell polarization and migration on 2D surfaces, it is crucial for regulating the cell’s responses to mechanical cues.

Download our Journal Club pack to aid your discussion of Graham et al.’s study and its implications for cell migration and mechanosensation. The pack includes a complete PDF of the paper, supplemental videos, and the latest biosights video podcast, which features an interview with the paper’s first author, David Graham, and its two senior authors, Jim Bear and Keith Burridge (University of North Carolina at Chapel Hill).