« Enucleated cells in migration and mechanotransduction | Main | BBSome trains enable transition zone crossing »

April 02, 2018

Formins are required for invasion

The actin cytoskeleton and its regulators play key roles in the maturation and stabilization of the focal adhesions but how adhesion maturation affects tissue morphogenesis is largely unknown. Fessenden et al. reveal that the actin-nucleating formin protein Dia1 promotes branching morphogenesis by stabilizing adhesions that are required for epithelial tissues to initiate invasion.

Download our Journal Club pack to aid your discussion of Fessenden et al.'s study and its implications for tissue morphogenesis and cancer metastasis. The pack includes a complete PDF of the paper, supplemental videos, and the latest biosights video podcast, which features an interview with the paper's senior author, Margaret Gardel (University of Chicago).

Posted at 07:51 AM |

| |

Comments

Feed You can follow this conversation by subscribing to the comment feed for this post.

Verify your Comment

Previewing your Comment

Posted by:  | 

This is only a preview. Your comment has not yet been posted.

Working...
Your comment could not be posted. Error type:
Your comment has been saved. Comments are moderated and will not appear until approved by the author. Post another comment

The letters and numbers you entered did not match the image. Please try again.

As a final step before posting your comment, enter the letters and numbers you see in the image below. This prevents automated programs from posting comments.

Having trouble reading this image? View an alternate.

Working...

Post a comment

Comments are moderated, and will not appear until the author has approved them.

Your Information

(Name is required. Email address will not be displayed with the comment.)

About Journal Club

  • The Journal of Cell Biology’s Journal Club packs are designed to enhance discussion of the latest research published in the JCB. Each month, we select an outstanding recent paper from the journal and provide links to download the manuscript pdf, a PowerPoint file of the paper’s figures, supplementary videos, and an accompanying biosights video, featuring interviews with the paper’s authors.

Archives

More...